Generic Alkacel

Common use

Alkacel is used in the treatment of various types of cancer, including multiple myeloma, ovarian cancer, and some leukemias and lymphomas. It contains melphalan, an alkylating agent that interferes with DNA replication in cancer cells, stopping their growth and causing them to die. It is often used in combination with other chemotherapy drugs or as part of a stem cell transplant regimen.

Dosage and direction

The dosage of Alkacel varies depending on the type of cancer, the patient's body weight, and their overall health. It is typically given either orally or intravenously. The drug is usually administered in cycles, with a period of treatment followed by a period of rest. The specific dosage and duration of treatment should be determined by a doctor based on the individual’s condition.

Precautions

Before starting treatment with Alkacel, patients should inform their doctor if they have a history of liver or kidney disease, infections, or bone marrow problems. Alkacel can suppress bone marrow function, which may lead to low blood cell counts. Regular blood tests are required during treatment to monitor these functions. It may also increase the risk of infections, bleeding, or other complications.

Contraindications

Alkacel is contraindicated in patients with known hypersensitivity to melphalan or any other components of the drug. It should not be used during pregnancy or breastfeeding due to potential harm to the fetus or infant. Patients with severely impaired bone marrow function should not use Alkacel without careful evaluation by their doctor.

Possible side effects

Common side effects of Alkacel include nausea, vomiting, fatigue, loss of appetite, and diarrhea. Bone marrow suppression can result in anemia, reduced immunity, easy bruising, or bleeding. Other side effects may include mouth sores, hair loss, and skin rashes. Serious side effects, such as secondary cancers or lung toxicity, may also occur but are rare.

Drug interaction

Alkacel may interact with other chemotherapy drugs, immunosuppressants, and medications that affect bone marrow function. The use of live vaccines is not recommended during treatment with Alkacel. Patients should inform their doctor about all medications, including over-the-counter drugs and supplements, before starting treatment.

Missed dose

If a dose is missed, the patient should contact their doctor immediately for instructions. In general, missed doses should not be doubled to make up for the missed one, as this can increase the risk of side effects.

Overdose

An overdose of Alkacel can cause severe side effects, including significant bone marrow suppression, gastrointestinal problems, and damage to internal organs. In case of overdose, seek emergency medical attention immediately.

Storage

Alkacel should be stored at room temperature, away from moisture and heat, and kept out of reach of children. The medication should not be used after the expiration date printed on the packaging. For intravenous formulations, follow specific storage instructions provided by the manufacturer.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)