Generic Amlodipine

Common use

This medication belongs to the group of calcium channel blockers. Amlodipine selectively blocks channels of L-type (one of six types of channels in tissues) located in a vascular wall, myocard and in particular in cells of conducting and contractile systems of myocardium. By blocking Ca+ ions transfer through membrane Amlodipine decreases tone of vessels, arterial pressure. The medication is used to treat hypertension, ischemic heart disease, angina.



Dosage and direction

Do not take this drug if it was not administered to you. Follow all directions of your doctor. It is possible to take Amlodipine with or without food. As it is metabolized in liver it should be administered cautiously in patients with liver failure.



Precautions

Avoid drinking alcohol. Before taking Amlodipine, inform your doctor if you have congestive heart failure or liver disease.



Contraindications

Individual hypersensitivity, arterial hypotension, cardiogenic shock, pregnancy, breastfeeding. Cautiousness is important when Amlodipine is administered in patients with chronic heart failure diabetes, lipid metabolism disorders, liver failure and to persons younger 18 y.o.



Possible side effect

The most common side effects are edema of lower extremities and headache. Contact your doctor for medical attention if your feel them and also swelling in your hands, ankles, or feet, chest pain, slow, fast, or pounding heartbeats, easy bruising or bleeding, unusual weakness, numbness, burning, pain, or tingly feeling, jaundice.



Drug interaction

Medications which contain Á2+ may decrease Amlodipine effect. Non-steroid anti-inflammatory medications and estrogens may decrease effectiveness of Amlodipine. Diuretics may increase Amlodipine activity. Concomitant taking with medications containing lithium might aggravate their toxicity.



Missed dose

If you forgot to take a dose take it as soon as you remember unless it is almost time for the next intake. If so do not take the missed dose and resume your regular schedule. Do not compensate the missed dose by taking an extra one.



Overdose

If you experience tingly feeling, severe dizziness, and fainting seek for immediate medical help.



Storage

Keep at room temperature, 15-30 C (59-86 F), in a light-resistant container away from moisture.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)