Combigan

Common use
Combigan eye drops are used to lower elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It combines Brimonidine, an alpha-agonist, and Timolol, a beta-blocker, to reduce fluid production and enhance fluid drainage in the eye.

Dosage and direction
Instill one drop in the affected eye(s) twice daily, approximately 12 hours apart. Use the drops exactly as prescribed, and avoid touching the dropper tip to any surface to prevent contamination.

Precautions
Inform your doctor if you have heart conditions, asthma, diabetes, or circulation problems. Combigan may cause drowsiness or blurred vision, so caution is advised during activities that require alertness.

Contraindications
Do not use Combigan if you have asthma, severe chronic obstructive pulmonary disease (COPD), slow heart rate, or heart block. Avoid use if allergic to Brimonidine, Timolol, or other beta-blockers.

Possible side effect
Common side effects include eye discomfort, redness, dry mouth, and fatigue. Serious side effects may include slow heart rate, difficulty breathing, or severe allergic reactions.

Drug interaction
Combigan may interact with antidepressants (especially MAO inhibitors), blood pressure medications, and other beta-blockers. Inform your doctor about all medications you are currently taking.

Missed dose
If a dose is missed, apply it as soon as you remember. If it’s close to the next scheduled dose, skip the missed one—do not double the dose.

Overdose
Overdose may cause low blood pressure, dizziness, or respiratory issues, especially in children. Seek emergency medical help if an overdose is suspected.

Storage
Store Combigan drops at room temperature, away from heat and light. Keep the bottle tightly closed and out of reach of children.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)