Generic Disulfiram

Disulfiram is used to support the treatment of chronic alcoholism. It works by interfering with the metabolism of alcohol, causing unpleasant effects when alcohol is consumed. This creates a strong deterrent effect, helping patients maintain sobriety.

Dosage and Direction
Disulfiram is taken orally once daily, usually in the morning. The typical dose ranges from 250 mg to 500 mg per day, depending on the patient’s response. Treatment should start at least 12 hours after the last alcoholic drink.

Precautions
Before starting disulfiram, inform your doctor if you have liver disease, heart conditions, diabetes, epilepsy, or mental health disorders. Avoid all forms of alcohol, including hidden sources like mouthwash, sauces, and certain medications. Patients should be aware of the risks of severe reactions if alcohol is consumed during treatment.

Contraindications
Disulfiram is contraindicated in individuals with severe heart disease, psychosis, or known hypersensitivity to the drug. It should not be used in patients who are currently intoxicated or without their knowledge and consent.

Possible Side Effects
Common side effects include drowsiness, headache, metallic or garlic-like taste, and skin rash. If alcohol is consumed, symptoms like flushing, nausea, vomiting, palpitations, and low blood pressure may occur. Severe reactions can include respiratory distress, cardiovascular collapse, and seizures.

Drug Interaction
Disulfiram interacts with metronidazole, isoniazid, phenytoin, and anticoagulants like warfarin. Alcohol-containing products should be strictly avoided. Inform your doctor of all medications and supplements being used.

Missed Dose
If a dose is missed, take it as soon as remembered unless it’s close to the next dose. Do not double up. Consistent daily use is important for effectiveness.

Overdose
Symptoms of overdose include severe drowsiness, nausea, vomiting, and neurological symptoms. Seek emergency medical attention immediately. Treatment is supportive.

Storage
Store at room temperature, away from heat, moisture, and light. Keep out of reach of children and do not use expired medication.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)