Generic Duricef

Common use

Duricef belongs to the cephalosporin family of drugs, it causes bactericidal effect violating cell wall formation. It acts against a broad spectrum of gram positive bacteria like Staphylococcus. (both producing and non-producing penicillase) Streptococcus and gram negative microorganisms (Shigella, Salmonella, Escherichia coli, Haemophilus influenzae, Klebsiella, some strains of Proteus). This medication is used to treat infections of respiratory system, urinary tract, pelvic organs, skin and soft tissues, osteomyelitis, eye infections, etc. which are caused by susceptible microorganisms as well as for prevention of endocarditis, infectious complications after surgery.



Dosage and directions

This medication is recommended to take once or twice daily. A daily dose is 1-2 mg. Dosage is administered individually and should be corrected for children.



Precautions

Avoid drinking alcohol during your course of treatment. Special attention should be paid to possibility of pseudomembranous colitis development and toxicity caused by Clostridium difficile. If symptoms of diarrhea are not serious they disappear after the medication intake was discontinued. Inform your doctor if you are pregnant or going to become pregnant before to take this drug.



Contraindications

Hypersensitivity to Durisef or penicillins and penicillamine, pregnancy, breastfeeding. Cautiousness should be exercised in patients with chronic kidney failure, colitis in history.



Possible side effect

You may experience diarrhea, inflammation of the bowel (colitis), nausea, redness and swelling of skin, skin rash and itching, vaginal inflammation, vomiting, seizures in rare cases and only your doctor make decide correctly if there is need for you to continue to take this drug.



Drug interaction

Durisef increases toxicity of polymixines and aminoglycosides, diuretics affecting loop of Henle in kidneys. Risk of bleeding increases in combination with inhibitors of platelets aggregation and non-steroid anti-inflammatory medications.



Missed dose

Never take a double dose of this medication. If you take Durisef once daily skip your missed dose and take the medication as soon as you remember, next dose should be taken in 10-12 hours. If you take Durisef twice daily the period between doses should be 5-6 hours.



Overdose

In case of serious and persistent seizures, allergic reaction (hives, rash, swelling of face and tongue, vaginal itching), diarrhea or kidney failure consult your doctor.



Storage

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term. Suspension can be used during 14 days after its preparation and should be kept in a refrigerator.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)