Generic Enclomiphene

Common Use
Enclomiphene is a selective estrogen receptor modulator (SERM) used primarily in men to treat secondary hypogonadism and restore natural testosterone production. It stimulates the hypothalamic-pituitary-gonadal axis to increase luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which then signal the testes to produce testosterone. It is also being studied for use in male infertility and other hormone-related conditions.

Dosage and Direction
Enclomiphene is taken orally, usually once daily. Dosage may vary depending on testosterone levels and physician recommendations. Regular blood tests are required to monitor testosterone and hormone response during treatment.

Precautions
Inform your doctor if you have a history of liver disease, blood clots, or hormone-sensitive cancers. It is not intended for use by women, especially during pregnancy or breastfeeding. Men should be monitored for signs of elevated estrogen, such as gynecomastia or mood swings.

Contraindications
Enclomiphene should not be used by individuals with liver impairment, existing hormone-sensitive tumors (like prostate or testicular cancer), or known hypersensitivity to the drug. It is not recommended for use in women.

Possible Side Effects
Common side effects include headache, nausea, mood changes, or hot flashes. In some men, it may cause visual disturbances, increased aggression, or elevated estrogen levels. Rare but serious effects include blood clots or liver enzyme changes.

Drug Interaction
Enclomiphene may interact with medications affecting liver enzymes or other hormone therapies. Caution is advised when used with other SERMs or testosterone-boosting agents. Inform your doctor about all medications and supplements.

Missed Dose
If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed one. Do not take double doses.

Overdose
Symptoms of overdose are not well defined but may include hormonal imbalance or overstimulation of testosterone production. Seek medical attention if an overdose is suspected.

Storage
Store enclomiphene at room temperature in a dry place, away from light and moisture. Keep out of reach of children and do not use after the expiration date.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Аnу specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)