Generic Fludrocortisone

Common use

Florinef is a glucocorticoid (with ability to retain Na+, excrete K+, and facilitate edema formation) applied to treat low levels of corticosteroid hormones (Addison's disease). Medial use of Florinef consists in treatment of neurally mediated hypotension (condition when blood pressure reduces when standing) and POTS (increased heart rate when standing). Orthostatic hypotension (significant drops in blood pressure) may be caused by the disease itself or may be a side effect of the anti-parkinsonian medications. Florinef also can be used to treat chronic fatigue syndrome.



Dosage and direction

This medication must be taken exactly as directed. Never increase your dose or suddenly stop taking Florinef without directions of your physician as it may increase side effects.



Precautions

This medication may be harmful to an unborn baby, so consult your doctor if you are pregnant, plan to be pregnant or breastfeed.



Contraindications

For short taking a single contraindication is hypersensitivity to the components of Florinef. The drug should be prescribed with cautiousness in case of parasitic and infectious diseases of viral, fungal or bacterial origin, just after vaccination, immunodeficient conditions, acute gastrointestinal diseases, diabetes, just after myocardial infraction, high blood pressure severe kidney or livery failure, osteoporosis and others.





Possible side effect

This medication is generally well tolerated though in case of: upset stomach, stomach irritation, vomiting, headache, dizziness, insomnia, swelling of the hands or feet, rapid weight gain, water retention, restlessness, depression, anxiety, acne, increased hair growth, easy bruising, irregular or absent menstrual periods, notify your doctor.



Drug interaction

Florinef increases effect and toxicity of glucocorticoids, may interact with antiinflammatory drugs (NSAIDs, such as ibuprofen), barbiturates, bosentan, estrogens and male hormones, certain heart medicines, diuretics, oral blood thinners, vaccines, aspirin, cyclosporine, pyridostigmine, neostigmine, drugs to treat diabetes. Also warn your doctor if you are a frequent user of drinks with caffeine or alcohol, if you smoke.



Missed dose

If you missed a dose take it as soon as you remember, but not if it is almost time of the next intake by your schedule. If it happened skip the missed dose. Do not try to compensate a missed dose by taking an extra one.



Overdose

Seek emergency medical attention if you suppose that too much of Florinef was taken. Signs of overdose symptoms may be: hypertension, edema, hypokalemia, excessive increase in weight, and increase in heart size.



Storage

Keep at room temperature away from moisture and sunlight.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)