Generic Gutron

Common Use
Midodrine is prescribed to patients with symptomatic orthostatic hypotension who experience dizziness or fainting upon standing. It helps raise blood pressure by stimulating alpha-1 adrenergic receptors in blood vessels. The medication improves the ability to stand and perform daily activities.

Dosage and Direction
The usual starting dose for adults is 2.5–10 mg three times daily during daytime hours. Doses are typically taken at intervals of 3–4 hours and not close to bedtime to avoid high blood pressure while lying down. Follow your doctor’s instructions carefully and do not exceed the prescribed dose.

Precautions
Before using Midodrine, inform your doctor if you have heart disease, kidney problems, urinary retention, or thyroid disorders. Blood pressure should be monitored regularly during treatment. Avoid taking the medication late in the evening.

Contraindications
Midodrine should not be used in patients with severe heart disease, acute kidney disease, urinary retention, or uncontrolled hypertension. It is also contraindicated in patients with hypersensitivity to the drug.

Possible Side Effects
Common side effects include tingling of the scalp, chills, goosebumps, itching, or urinary urgency. In some cases, high blood pressure when lying down may occur. Seek medical advice if severe symptoms develop.

Drug Interaction
Midodrine may interact with other medications that increase blood pressure or affect heart rate. Combining it with certain antidepressants or decongestants may increase the risk of hypertension. Inform your healthcare provider about all medications and supplements you take.

Missed Dose
If a dose is missed, take it as soon as you remember during the day. Skip the missed dose if it is close to bedtime or the next scheduled dose. Do not double the dose.

Overdose
Overdose may cause severe hypertension, slow heart rate, or urinary retention. Seek immediate medical attention if overdose is suspected. Treatment is usually supportive and symptom-based.

Storage
Store Midodrine at room temperature, away from moisture and direct sunlight. Keep out of reach of children. Do not use after the expiration date.

Disclaimer
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)