Generic Lioresal

Common use

Baclofen is an analogue of gamma-aminobutyric acid (GABA). It is used to treat stiffness, rigidity and tension in muscles (spasticity). This medicine helps to relieve spasms and cramping of muscles. It is also used to treat symptoms of multiple sclerosis or spinal cord injury.



Dosage and direction

Take Lioresal by mouth with a glass of water, with or without food. Take the drug only as prescribed because dosage and schedule may vary depending on your condition and other factors. Avoid cutting, crushing or chewing this medicine.

Do not take the medicine more often than it is prescribed. Do not give up taking it except on the advice of your doctor.

It may need time for the medicine to help.

Consult your doctor concerning proper dose for you.



Precautions

Before taking Baclofen tell your doctor or chemist if you are allergic to it; or if you have other allergies.

Inform your doctor or chemist if you have bipolar confusion, eye, liver or kidney problems.

Avoid drinking alcohol and smoking while being treated with this medication.

Cautoin is advised while using Baclofen by pregnant/nursing women or children. Aged people can be more sensitive to side effects of the medicine.

During the pregnancy this treatment should be used only when strongly necessary.

As this medicament can be absorbed by skin, women who are pregnant or may become pregnant should not manipulate this medicine.



Contraindications

Lioresal should not be used by patients having demonstrated a reaction of hypersensitivity to Baclofen.



Possible side effect

The most common side effects are skin rash, itching or hives, chest pain, headache, nausea, etc.

A very serious allergic reaction rarely occurs. Many people using this medicine do not have serious side effects.

Turn to your doctor or pharmacist for more details.

In case you notice the effects not listed here, contact your doctor or pharmacist.



Drug interaction

Tell your doctor or pharmacist of all prescription and nonprescription/herbal products you used before using this medication.

Baclofen can interact with:

* medicines for depression, anxiety, and other mental conditions;

* medicines for pain (codeine, oxycodone, tramadol, and propoxyphene);

* antihistamines.

Turn to your doctor or pharmacist for more details.



Missed dose

If you have missed your dose, take it as soon as you remember. If you see that it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not take your dose twice.



Overdose

If you think you have used too much of this medicine seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.



Storage

Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store your drugs in the bathroom. Keep all drugs away from reach of children and pets.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)