Meloset

Common use

Meloset aids people who are having trouble sleeping, as well al those who suffer from jet lag and attention deficiency human disorder. The natural hormone melatonin, produced by our pineal gland is the one that keeps our sleep-wake cycles in balance. When the pineal gland stops producing enough hormone, that balance shifts, causing people to have insomnia which leads to a state of constantly being tired and not be able to do anything. Being a synthethic version of the hormone Melatonin, Meloset aids people to complete their everyday activities by regulating their sleep pattern and will overall result in an increase of their quality of life.

Dosage and direction

The correct way to administer Meloset is the way your doctor has prescribed it. It can be different from one human to another depending on your past medical history, health and the severity of the condition that has prompted you to see a doctor in the first place. In general, doctors will prescribe the usage of Meloset two hours before bedtime. Thus, the effectiveness is reached by the time you go to bed. The tablets of Meloset should be taken by swallowing, without chewing it, with a large glass of water. Although there is no evidence that you should have a snack prior to taking the tablet, it is indicated to in case you are experiencing nausea.

Precautions

Do not drive or operate heavy machinery after taking Meloset, as your reflexes and senses may be dimished which can lead to accidents.
Do not alter the dose prescribed by your physician as this may have serious implications and may even worsen your condition.
Meloset may contain certain active agents that can cause allergic reactions. If you are experiencing one or more of the following: difficulty breathing or swallowing, chest tightness, swelling, skin rashes, seek emergency care immediately.

Contraindications

Do not take Meloset with alcohol, as it may result in an enhancement of the effects.
Do not take Meloset when pregnant, as there are little to no studies done on females during pregnancy.
Patients having underlying conditions such as kidney or liver disease should first consult their doctor before taking Meloset, because there are not enough studies that have been made on the matter.
Talk to your doctor before taking Melatonin in case you are taking any other medicine or any other types of supplements.

Possible side effect

Possible side effects include headaches, dizziness, being drowsi in the day time, fatigue, throat inflammation, mood changes, irritability, restlessness, nervousness.

Drug interaction

The following drugs have been found to have certain interactions with Meloset: Fluvoxamine (Luvox) , sedative-type medications, blood-thinner medications (anticoagulants) such as warfarin, heparin, or aspirine, medications for diabetes; blood sugar may increase with melatonin caffeine, nifedipine.

Missed dose

In case you have missed a dose, do not take the following day a double dose to make up for the one you missed. Strictly follow the doctor’s orders at all times.

Overdose

In case you are under the impression that you have overdosed, immediately contact 1-800-222-1222, or present yourself to your local emergency room as soon as possible.


Storage

Store Meloset at room temperature, avoiding moisture and direct sunlight and in a place where children do not have access.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)