Generic Motilium

Common use

Motilium blocks pereferal and central dophamin receptors, removes inhibiting influence of dophamin on motor activity of gastrointestinal tract and increases evacuative and tone of stomach. It has anti-vomiting effect, soothes hiccup and nausea. Motilium is used to treat vomiting of different origin, hiccup, atonic gastrointestinal tract, necessity to accelerate peristalsis for X-ray examination, dispepsia caused by slow stomach, gastroesophageal reflux disease, esophagitis, gas, heartburn with or without passage of gastric contents into the mouth.



Dosage and directions

Take Motilium orally 30 minutes before a meal. In adults and children older than 5 y.o. take 10 mg 3-4 times a day when dispepsia is diagnosed. In patients with severe nausea and vomiting Motilium daily dose is 20 mg 3-4 times a day. In patients with kidney failure correction of the dose is necessary, number of daily intakes should not exceed 1-2 times. This is only general recommendations and for each individual case consult your doctor as different conditions require different correction of the dose.



Precautions

If you are pregnant or think you might be pregnant first consult your doctor or pharmacist before taking Motilium or any other medicine. Do not take Motilium if you are breast-feeding.



Contraindications

Hypersensitivity, bleeding in gastrointestinal tract, mechanical intestinal obstruction, perforation of the stomach or intestines, prolactinoma, infancy (younger than 5 y. o. and ones whose weight is less than 20 kg). Caution should be experienced in patients with renal / hepatic insufficiency, during lactation, pregnancy.



Possible side effect

Among most common side effects these can occur: transient spasms of the intestine, allergic reactions (skin rash, urticaria), hyperprolactinaemia (galactorrhoea, gynecomastia).



Drug interaction

Cimetidine and sodium bicarbonate reduce effects of Domperidone. Anticholinergic medications neutralize effect of Motilium. Blood levels of Motilium are increased by azole antifungal agents, macrolide antibiotics, HIV protease inhibitors, nefazodone (antidepressant). Motilium is compatible with antipsychotic (neuroleptics) medications, dopamine receptor agonists (bromocriptine, L-dopa). Simultaneous treatment with paracetamol and digoxin had no effect on the concentration of these medications in the blood.



Missed dose

If you missed a dose take it the soonest. If it is almost time of your next dose just skip it and return to your regular dosage schedule.



Overdose

Symptoms of overdose may include drowsiness, disorientation, extrapyramidal disorder (especially in children). If you think that took too much of Motilium and experience symptoms listed above contact your doctor immediately, you may need a medical help.



Storage

Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)