Generic Serc

Common Use

Serc (Betahistine dihydrochloride) is primarily used to treat Ménière’s disease, a disorder of the inner ear that causes episodes of vertigo (a spinning sensation), tinnitus (ringing in the ears), hearing loss, and a feeling of fullness or pressure in the ear. Betahistine acts as a histamine analog, improving blood microcirculation in the inner ear, which helps to reduce the pressure of excess fluid and restore balance.

Dosage and Direction

The standard adult dose is 16 mg taken two to three times daily, preferably with meals to reduce gastrointestinal side effects. Tablets should be swallowed whole with water. The dosage may be adjusted based on the severity of symptoms and the patient's response to treatment. Consistency is important for maximum effectiveness; it may take a few weeks to notice significant improvement.

Precautions

Before using Serc, inform your doctor if you have:

• Asthma (due to potential bronchospasm),

• Peptic ulcer or a history of stomach ulcers (as betahistine may increase gastric acid secretion),

• Hypotension (low blood pressure),

• Pregnancy or breastfeeding — safety is not fully established.

Caution is also advised in elderly patients or those with impaired liver/kidney function.

Contraindications

• Known hypersensitivity to betahistine or any of the tablet’s components.

• Pheochromocytoma (a rare adrenal gland tumor), as betahistine may induce a hypertensive crisis.
  It should not be used without medical supervision in children or adolescents due to lack of data on safety and efficacy.

Possible Side Effects

Common side effects may include:

• Mild gastrointestinal disturbances: nausea, dyspepsia, bloating.

• Headache or dizziness during the initial phase of treatment.

• Allergic reactions, such as rash, itching, or hives (rare).
  Most side effects are mild and transient, and improve as the body adjusts to the medication.

Drug Interaction

• Betahistine may interact with antihistamines (e.g., cetirizine, loratadine), potentially reducing the effectiveness of either drug.

• Monoamine oxidase inhibitors (MAOIs), including some antidepressants, may increase betahistine levels and effects — caution is advised.

• No significant interaction with alcohol or common antibiotics, but it's best to consult a physician before combining medications.

Missed Dose

If a dose is missed, take it as soon as you remember.
If it's almost time for your next scheduled dose, skip the missed dose — do not take a double dose to make up for it.

Overdose

Although rare, symptoms of overdose may include:

• Nausea, vomiting, stomach pain, drowsiness, or seizures in extreme cases.
  In the event of suspected overdose, seek immediate medical assistance or contact a poison control center.

Storage

• Store the medication at room temperature (15–25°C / 59–77°F).

• Keep away from heat, moisture, and direct sunlight.

• Store in the original blister packaging, out of reach of children and pets.

• Do not use after the expiration date printed on the box.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)