Generic Toficalm

Common Use
Toficalm (Tofisopam) is a benzodiazepine derivative used to treat anxiety and stress-related disorders. Unlike traditional benzodiazepines, it has minimal sedative effects and does not cause significant muscle relaxation or cognitive impairment.

Dosage and Direction
The recommended dosage is usually 50–150 mg per day, divided into multiple doses as prescribed by a doctor. It should be taken orally with water, preferably after meals, to reduce potential stomach discomfort.

Precautions
Patients with liver or kidney disorders should use Toficalm with caution. Alcohol consumption should be avoided, as it may enhance side effects. It is not recommended for use in children and pregnant or breastfeeding women without medical supervision.

Contraindications
Toficalm is contraindicated in patients with hypersensitivity to tofisopam or other benzodiazepines. It should not be used in individuals with severe respiratory insufficiency, myasthenia gravis, or acute intoxication with alcohol or CNS depressants.

Possible Side Effects
Common side effects include headache, dizziness, nausea, and mild gastrointestinal discomfort. In rare cases, allergic reactions, mood changes, or palpitations may occur. If severe side effects develop, medical attention is required.

Drug Interaction
Toficalm may interact with alcohol, sedatives, and other CNS depressants, enhancing their effects. It can also alter the metabolism of some drugs processed by liver enzymes, requiring dosage adjustments.

Missed Dose
If a dose is missed, it should be taken as soon as remembered. However, if it is close to the next scheduled dose, the missed dose should be skipped. Doubling the dose is not recommended.

Overdose
Symptoms of overdose may include drowsiness, confusion, low blood pressure, and respiratory depression. In case of overdose, immediate medical assistance should be sought, and symptomatic treatment may be required.

Storage
Store Toficalm in a cool, dry place at a temperature below 25°C, away from direct sunlight and moisture. Keep it out of reach of children and pets to prevent accidental ingestion.

Disclaimer
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)