Generic Tretinoin Cream

Common Use
Tretinoin is a topical retinoid (vitamin A derivative) used to treat acne, reduce fine wrinkles, improve skin texture, and treat hyperpigmentation. It works by increasing skin cell turnover, unclogging pores, and stimulating collagen production. Tretinoin is also used in oral form (under strict medical supervision) for acute promyelocytic leukemia (APL).

Dosage and Direction
Tretinoin is usually applied once daily at night to clean, dry skin in a thin layer. Avoid applying near the eyes, mouth, or open wounds. Use sunscreen daily, as tretinoin increases sun sensitivity. Results may take several weeks to become noticeable.

Precautions
Tell your doctor if you have eczema, rosacea, or sensitive skin. Avoid waxing or using abrasive skincare products on treated areas. Do not use during pregnancy (topical or oral) due to the risk of birth defects; use effective contraception while on treatment.

Contraindications
Do not use tretinoin if you are allergic to retinoids or any ingredients in the product. It is contraindicated in pregnancy (both topical and oral forms). Oral tretinoin for leukemia must be avoided in patients with severe liver dysfunction or high triglycerides.

Possible Side Effects
Common side effects include skin dryness, redness, peeling, burning, and increased sensitivity to sunlight. These usually lessen with continued use. Serious but rare side effects include severe skin irritation, swelling, and, in oral form, headache, bone pain, or vision problems.

Drug Interaction
Avoid combining tretinoin with other irritating topical products like benzoyl peroxide, alcohol-based toners, or exfoliants unless directed by a doctor. Oral tretinoin may interact with tetracyclines, vitamin A supplements, and certain antifungals. Always inform your doctor about all medications and supplements you use.

Missed Dose
If you miss a topical dose, apply it as soon as possible unless it's close to the next application. Do not apply extra product to make up for a missed dose. For oral tretinoin, follow your doctor's guidance.

Overdose
Topical overdose is unlikely but may cause severe skin irritation or peeling. Oral overdose is more serious and may include headache, dizziness, vomiting, or signs of vitamin A toxicity. Seek medical attention if overdose is suspected.

Storage
Store tretinoin at room temperature away from light and moisture. Keep the container tightly closed and out of reach of children. Do not freeze or expose to excessive heat.

Disclaimer
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Апу specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)