Generic Trihexyphenidyl

Common use

Trihexyphenidyl is used to treat symptoms of Parkinson's disease. It can be prescribed alone or in combination with other medications. It controls rigidity, drooling, tremors and other Parkinson's disease. Also it can be prescribed to prevent similar symotoms caused by chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon) and others.



Dosage and directions

Artane should be used only by the patient for whom it has been prescribed. Do not take less or more or take it more often than prescribed by your doctor.

Artane dosage depends on your conditions it should be taken exactly as prescribed. Usually Artane is prescribed as a capsule, tablet and liquid taken 3-4 times a day with food at bedtime. Controlled-released Artane should be taken once to twice a day every 12 hours.



Precautions

Before taking Artane discuss with your doctor if you have liver o kidney disease. Use it with caution.

The medicine may cause dizziness or lightheadedness. Avoid drink alcohol o other medicines. It can make worse the side effects. Do not drive or perform other unsafely work until you know how you react to this drug. Do not eat grapefruit or drink grapefruit juice while you take Artane Tablets. Proper dental care is needed while you are taking Artane Tablets. Brush and floss your teeth and visit the dentist regularly. If your symptoms do not improve or if they worsen, contact your doctor.



Contraindications

You may need special dosage adjustment or you may not be able to take this drug if you have liver o kidney infection or if you have gastrointestinal problems.



Possible side effects

The most serious side effects are severe neutropenia (low white blood cells), hemorrhage (gastrointensial or cerebral), thrombotic thrombocytopenic pupura (TTP), headache, indigestion, flushing. Seek medical help immediately if your side effects do not ease off during several hours.



Drug interaction

Artane interacts with certain products phenytoin (Dilantin); tamoxifen (Nolvadex); tolbutamide (Orinase); torsemide (Demadex); fluvastatin (Lescol); a blood thinner such as warfarin (Coumadin), heparin, ardeparin (Normiflo), dalteparin (Fragmin), danaparoid (Orgaran), enoxaparin (Lovenox), or tinzaparin (Innohep); (Activase), anistreplase (Eminase), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), ticlopidine (Ticlid), and urokinase (Abbokinase). Disscuss with your doctor if you are taking the above mentioned drugs.



Missed dose

If you miss a dose take it as soon as you remember. If it is almost time for the next dose, skip the Missed Dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.



Overdose

The symptoms of Artane overdose aren't known. If you think that you overdosed the medicine seek medical help immediately.



Storage

Keep at the temperature between 59–86F (15–30 C), away from heat, moisture, light and children.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)