Generic Trimetazidine

Common use

Trimetazidine is a metabolic anti-anginal agent used to manage chronic stable angina pectoris (chest pain caused by reduced blood flow to the heart). It works by improving energy metabolism in heart cells, helping them function more efficiently under low-oxygen conditions. Unlike other heart medications, it does not affect blood pressure or heart rate. It is often used as an add-on therapy when standard treatments are not enough.

Dosage and direction

The typical dose is 35 mg twice daily, taken with meals to enhance absorption and reduce stomach upset. Tablets should be swallowed whole with water—do not crush or chew them. Always follow your doctor’s instructions and do not exceed the recommended dose. Dose adjustments may be needed for elderly patients or those with kidney impairment.

Precautions

Before taking trimetazidine, tell your doctor if you have Parkinson’s disease, movement disorders, or severe kidney problems. It should not be used to treat acute angina attacks and is not a substitute for nitrates or beta-blockers in emergency cases. Caution is advised in the elderly due to a higher risk of side effects like tremors or instability. Inform your physician of any neurological symptoms that may develop during treatment.

Contraindications

Trimetazidine is contraindicated in patients with Parkinsonian symptoms, restless leg syndrome, or other movement disorders. It should not be used in individuals with severe renal impairment (creatinine clearance < 30 mL/min). Patients with known hypersensitivity to trimetazidine or its excipients must avoid this drug. It is also not recommended during pregnancy or breastfeeding unless clearly needed.

Possible side effect

Most side effects are mild and reversible. Common ones include nausea, abdominal pain, headache, and dizziness. Rare but serious effects include movement disorders such as tremors, gait instability, or rigidity. If you experience any abnormal movements or neurological symptoms, contact your doctor immediately.

Drug interaction

Trimetazidine has a low potential for drug interactions. However, it should be used cautiously with medications that affect kidney function or have neurological effects. Always inform your healthcare provider of all medications and supplements you are taking. No major food or alcohol interactions are known.

Missed dose

If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed one—do not double the dose. Continue with your normal dosing schedule. Missing occasional doses may not cause serious issues, but consistent use is essential for long-term benefit.

Overdose

Overdose is rare but may lead to dizziness, nausea, or movement disorders. In severe cases, seek emergency medical attention. Supportive care is usually sufficient. There is no specific antidote for trimetazidine overdose.

Storage

Store trimetazidine at room temperature (15°C to 25°C / 59°F to 77°F), away from moisture and heat. Keep the medication in its original packaging. Do not use expired tablets, and keep out of reach of children. Dispose of unused medication safely according to local guidelines.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)