Generic Ziprasidone

Common use

Geodon is used to treat schizophrenia and the manic episodes of bipolar disorder. It possesses high affinity to dopamine D2-receptors and more significant affinity to serotonin 5-HT2A-receptors. It is supposed that the medication blocks serotonin and dopamine receptors and inhibits the re-uptake of serotonin and norepinephrine in the brain and this way shows its anti-psychotic activity. Geodon is used to treat psychotic disorders, schizophrenia, and affective disorders. Due to its potentially serious side effects it is administered only if other medications have proved inadequate.



Dosage and direction

The recommended dose for adults is 40 mg two times a day and should be corrected for each particular condition. Geodon is available in dosage of 20 mg, 40 mg, and 80 mg. Maximal dose is 160 mg a day. Take it orally with a meal. Dose correction is required in patients with with hepatic impairments.



Precautions

Cautiousness is required when the medication is administered in patients with severe hepatic failure, bradicardia, electrolyte disorders. This medication causes drowsiness so certain cautiousness is required while driving and operating a machinery.



Contraindications

Geodon cannot be used in pregnant and breastfeeding women excluding cases when supposed benefit prevails over potential risk for the unborn baby. Patients hypersensitive to the medication cannot take it. Individuals with the extension of the QT interval (including congenital syndrome of extension of the QT interval ), recent acute myocardial infarction, decompensated heart failure, arrhythmia treated with administration of class IA and III antiarrhythmic drugs cannot be treated by Geodeon. Effects of the medication in the patients under 18 y.o. have not been studied.



Possible side effect

Side effects cannot be anticipated and if occur they are transient. Adverse reactions include: asthenia, accidental injury, headache, drowsiness, dizziness, tremor, anorexia, vomiting, cold symptoms, upper respiratory infection, stuffy and runny nose, nausea, constipation, diarrhea, indigestion, cough, dry mouth, fatigue, involuntary muscle contractions, muscle aches, muscle tightness, rapid heartbeat, rash, skin fungus, twitching, vision problems, weakness.



Drug interaction

Thioridazine (Mellaril), moxifloxacin (Avelox), pimozide (Orap), quinidine (Quinidex), dofetilide (Tikosyn), sotalol (Betapace), and sparfloxacin (Zagam) should not be taken with Geodon due to increased risk of serious disturbances in the heart rhythm. Carbamazepine (Tegretol) diminish effects of Geodon while Ketoconazole (Nizoral) acts just the opposite as well as itraconazole (Sporanox), fluconazole (Diflucan), nefazodone (Serzone), verapamil (Calan, Isoptin, Verelan), erythromycin, clarithromycin (Biaxin), and diltiazem (Cardizem, Tiazac, Dilacor).



Missed dose

Take the missed dose as soon as you remember. If it is almost time of your next dose just skip the missed dose and return to your schedule. Do not double dose this medication to make up the missed dose.



Overdose

Symptoms of overdose may include anxiety, drowsiness, tremors, slurred speech, and transient high blood pressure. Contact your doctor immediately in case of suspected overdose.



Storage

Store at room temperature, 15-30 C (59-86 F) away from sunlight, moisture, children and pets.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Clinical Verification

Last Clinically Updated: August 15, 2026

Written By

Dr. Elena Vance, PharmD

Clinical Specialist in Neuropharmacology

Fact Checked By

Marcus Thorne, MS

Biomedical Data & FDA Label Verification

Medically Reviewed By

Dr. Arthur Campbell, MD

Board-Certified Psychiatrist (ABPN)